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【Objective】 To investigate the prevalence of depression in blood donors and analyze the related factors, so as to develop a rapid depression screening model for blood donors. 【Methods】 A total of 13 015 street whole blood donors in Guangzhou Blood Center during May to August, 2020 filled in an anonymous e-questionnaire, including social demography information and the Patient Health Questionnaire-9 before donation. The cut-off value for detecting depression was 10. Logistic regression by SPSS 26.0 was used to analyze depression related factors. 2-level decision tree with 30/10 as the minimum number of cases in parent/child node, 10-fold cross validation was used to cut items of PHQ-9 to form the depression screening model. 【Results】 364 out of 13 015 (2.80%) street whole blood donors reported a score ≥ 10. Donors with 18-29 years old (P <0.05), unmarried (P<0.05), less than 50 000 RMB household income per year (P< 0.05) were more prone to depression. 81.96% donors in "<10 scores" group, while 3.85%donors in "≥ 10 scores" group were in two terminal nodes formed by Item-6, 2 and 4 of PHQ-9. After verification by the 10 fold crossover method, the estimated misclassification risk of the model was 1.7%. 【Conclusion】 The screening prevalence of depression based on PHQ-9 in Guangzhou blood donors was 2.8%(95% CI: 2.52%-3.09%) . Donation frequency was not related to depression. A rapid and efficient depression screening model for blood donors based on item-6, 2 and 4 of PHQ-9 was developed.
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With accelerated aging process of the population, femoral intertrochanteric fractures have gradually become another major social health problem in China. Internal fixation is still the gold standard treatment for the fractures. Fracture reduction is the first step of the treatment and also the first element that affects the treatment efficacy. It is still controversial in clinical practice how to evaluate the quality of fracture reduction during internal fixation of the fractures. This article systematically expounds and analyzes the 7 systems of judging criteria for the reduction of intertrochanteric fractures from the aspects of fracture alignment, fracture apposition, difference in judgment criteria, and difference in imaging methods, in order to provide a reference for reaching consensus and improving curative effects.
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【Objective】 To study the demographic characteristics of whole blood donors aged 56 to 60 in Guangzhou, so as to provide reference for smooth implementation of the recruitment and management of elderly blood donors in Guangzhou. 【Methods】 The data of whole blood donors, aged 56 to 60, in Guangzhou Blood Center from July 1, 2016 to June 30, 2021 were retrospectively analyzed, and such characteristics as the number of blood donations, gender, donation frequency, donation volume, occupation and educational background were analyzed. 【Results】 A total of 3 996 blood donors aged 56 to 60, including 3 013 males and 983 females, gave 14 416 donations during July 1, 2016 to June 30, 2021, with the proportion of 400 mL specification at 64.1% (6 999/10 918) of males, which was significantly higher than that of females 57.7% (2 017/3 498). The number of blood donors had been decreasing year by year, but the ratio of men to women was stable.The education background of blood donors were mainly high school, junior college, and undergraduate education, accounting for more than 60% in total, and the proportion of undergraduate and graduate degree trended to grow. Staff, workers, medical staff and civil servants were the majorities, and the proportion of medical staff trended to grow. 【Conclusion】 Male blood donors aged 56 to 60 in Guangzhou showed stronger intention to donate blood, and the proportion of blood donors with better education and medical staff was on the rise.
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【Objective】 To analyze the researches on blood donation service during 2001 to 2020, explore the development of blood donation service in China and discover the hot spots and weaknesses in current research, aimed to provide reference for future research. 【Methods】 The research team, institutions and hotspots of related literature from China National Knowledge Infrastructure (CNKI) were analyzed using CiteSpace. 【Results】 After analyzing the selected 969 relevant literature, it is concluded that there is few communication between the core author teams. The inter-agency research network is not mature enough, and the cooperation and communication between institutions need to be further strengthened. The high-frequency keywords were volunteer donors, satisfaction, blood donation response and humanized service. Quality control in the blood donation service process, maintenance and recruitment of regular blood donors, and the establishment and improvement of voluntary blood donation teams were research hot spots. 【Conclusion】 China has made fruitful achievements in the research of blood donation service after 20 years of development. The key point of future research is to strengthen the cooperation between different research teams, integrate the first-line practice of blood collection and supply, as well as explore the individualized and localized theory of blood donation service.
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【Objective】 To further determine the relationship between blood donor role cognition and blood donation behavior, then prepare of blood donor role identity scale(BDRIS). 【Methods】 The preparation of the scale was divided into five stages. It includes literature retrieval, expert interview, construction of the basic framework of the scale, scale test and statistical index test. The study focused on items selection, dimensions identification, measurement reliability, content and structural validity. 【Results】 The blood donor role identity scale consisted of 35 items. Exploratory factor analysis divided the items into six common factors, including role identity, role expectation, current situation of blood collection and supply, role conflict, external reward and blood donation experience. The α of scale was 0.840. 【Conclusion】 The reliability and validity of the scale meet the basic measurement requirements, and the framework of the blood donor role scale is basically formed. It can be used as one of the means to explore the ways and mechanisms of the role identity of blood donors in blood donation behavior.
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【Objective】 To apply the spatial distribution analysis based on ArcGIS software, which has been applied widely in other fields, so as to analyze the intended locations for whole blood donation. 【Methods】 After a random stratified sampling was conducted among blood donors in the 17 donation sites during August 1st, 2021- July 30th, 2022, their intended blood donation locations were collected by an e-questionnaire. Addresses of donors′ intended donation locations were derived for GCJ-02 coordinates form and transformed by pandas module of Python to WGS84 coordinates, which further loaded to ArcGIS Arcmap module using Grouping Analysis for 17 median centers. The addresses of 17 blood donation sites in Guangzhou Blood Center were transformed to WGS84 coordinates and loaded to ArcGIS Arcmap module using the same methods for 3 ring buffer analysis. The criterion for judging whether the two were " matched" was whether the intended blood donation sites were covered by or adjacent to the 3 ring buffer zone of the existing blood donation sites. 【Results】 Of the 17 potential sites obtained from the spatial distribution analysis of 40 523 valid addresses of donors, 8 sites were covered or adjacent to the buffer of the existing donation sites, while the other 9 sites were far away from the existing donation sites. 【Conclusion】 By analyzing the spatial distribution of donors′ intended donation addresses, we can find out the service needs of donors for donating blood conveniently, which can provide basis for further blood donation service optimization.
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【Objective】 To analyze the related factors affecting first-time platelet donors to become regular donors in Guangzhou in 2018, so as to provide reference for the retention of platelet donors. 【Methods】 The data of 4 361 first-time platelet donors in Guangzhou in 2018, including age, gender, initial donation unit, time for the primary and secondary donation were collected. The relevant factors affecting first-time blood donors to become regular donors were analyzed by Logistic regression analysis. 【Results】 Among the influencing factors, first-time donors returned in the first month were more likely to become regular donors (5.569 times that of those did not return)(OR 95% CI: 4.748~6.533, P<0.05). First-time donors who aged 45~60, and initially donated 2 units were more likely to become regular donors than those aged 18~24(1.857 times) (OR 95% CI: 1.413~2.441, P<0.05), and those initially donated only one unit (1.695 time) (OR 95% CI: 1.486~1.933, P<0.05). 【Conclusion】 The returning in the first month, age and initial donation units predict long-term commitment for first-time donors. Encouraging first-time platelet donors to return within 1 month is more likely to convert them into regular blood donors.
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Objective:To investigate the correlation between social and linguistic parenting behaviors and developing capability of children with autism.Methods:From August 2020 to December 2020, the social and linguistic parenting behaviors of 302 parents of children diagnosed with autism were investigated in the outpatient department of the hospital.Meanwhile, the data of Gesell scale for children, the social life competence scale for infant and junior middle school students, the autism behavior checklist and the Cancy autism behavior scale were collected.SPSS 20.0 software was used for statistical analysis.Independent sample t test and analysis of variance were used to compare the social and linguistic parenting behaviors of different parents.Pearson correlation analysis was used to analyze the correlation between the social and linguistic parenting behaviors of parents and children's developmental ability and symptom severity. Results:There were no statistically significant differences in children's social and language development parenting behavior between father and mother ( t=1.033, P=0.303; t=-0.312, P=0.756). There were no statistically significant differences in children's social and linguistic parenting behaviors between fathers of different age groups ( F=1.425, P=0.244; F=1.127, P=0.345). Among mothers of different age groups, the social parenting behaviors of <30 years old and 30-34 years old groups were significantly better than those of 35-39 years old group ( F=3.374, P=0.019; LSD: P=0.010, P=0.006). Among fathers, the social parenting behavior( F=4.346, P=0.008; LSD: P=0.020, P=0.001) and social + linguistic parenting behavior in the graduate group and college group were significantly better than those in the high school/vocational group( F=3.965, P=0.012; LSD: P=0.020, P=0.002). Among mothers, the social parenting behavior ( F=2.812, P=0.040; LSD: P=0.008, P=0.023, P=0.009), linguistic parenting behavior ( F=3.769, P=0.011; LSD: P=0.010, P=0.025, P=0.001), social + linguistic parenting behavior ( F=3.654, P=0.013; LSD: P=0.005, P=0.015, P=0.002) in graduate and above groups were significantly better than those in college group, high school/vocational group, junior high school and below groups.The scores of social parenting behavior(40.72±6.80), linguistic parenting behavior(27.20±5.22), and social + linguistic parenting behavior(67.92±11.10) were significantly correlated with children’s fine motor(61.75±16.41)( r=0.193, P=0.001; r=0.153, P=0.009; r=0.190, P=0.001), cognition(68.28±16.83)( r=0.231, P=0.000; r=0.186, P=0.001; r=0.229, P=0.000), language(53.01±18.55) ( r=0.262, P=0.000; r=0.305, P=0.000; r=0.304, P=0.000) and social self-care(61.44±17.85) ( r=0.264, P=0.000; r=0.238, P=0.000; r=0.274, P=0.000). The scores of linguistic parenting behavior and social + linguistic parenting behavior were correlated with children's social life ability (8.65±0.89) ( r=0.142, P=0.046; r=0.140, P=0.049). There was no significant correlation between social parenting behavior, linguistic parenting behavior, social + linguistic parenting behavior and the scores of ABC scale (50.53±21.39) ( r=-0.089, P=0.336; r=-0.115, P=0.215; r=-0.107, P=0.250) and CABS scale (13.96±4.54) ( r=-0.050, P=0.490; r=-0.059, P=0.411; r=-0.058, P=0.421). Conclusions:The social and linguistic parenting behaviors are related to their age and educational level, and are significantly correlated to developing capability of children with autism, but have nothing to do with the severity of children's symptoms.
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【Objective】 To investigate the positive and negative influencing factors concerning repeated blood donation among college students, in order to provide reference for the maintenance and retention of college student blood donors. 【Methods】 The questionnaire was made in terms of motivators, barriers and social supports related to repeated blood donation based on relevant literature at home and broad and the results of semi-structured interviews. From November to December 2020, 1 200 college donors from 10 colleges in Guangzhou were selected. The results of questionnaires were analyzed with Chi-square test and multivariate logistic regression by SPSS 26.0. 【Results】 Good for health, shortage of blood, favorable policy concerning blood donation, and blood need of family members were the four motivators of repeated blood donation. The inconvenience of blood donation location and dissatisfaction with blood donation souvenir were the two barriers. In addition, encouragement from classmates and curiosity were the two motivators, and harmful to health was the barrier in first-time college blood donors. 【Conclusion】 Blood banks should strengthen the publicity of blood related knowledge, preferential policies concerning blood donation, and status of blood collection and supply, etc, make full use of the influence of peers and the favorable environment of colleges to form a right atmosphere for blood donation, and enhance the reputation and service of blood banks.
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【Objective】 To explore the effect of questionnaires on the re-recruitment of lapsed blood donors, and to ensure the retention of regular blood donors for blood supply in blood stations. 【Methods】 Blood Donation Motivation Questionnaire and Blood Donation Deterrents Questionnaire were designed for inactive and lapsing blood donors to inquire the motivation of the latest blood donation, such as "blood donation can save lives" and the reasons for no longer participating in blood donation, such as "there are no blood donation sites nearby", respectively. 13 093 blood donors with donation frequency ≥3 times and last donation during January 1 to May 17, 2018 in Guangzhou were selected as subjects. Text messages containing the links to the correspondent electronic questionnaires were sent to intervention group 1 (n=4 364) to fulfill the Blood Donation Motivation Questionnaire and intervention group 2 (n=4364) to fulfill Blood Donation Deterrents Questionnaire from May 18 to 25, 2020. None questionnaire was issued to the control group (n=4 365). The re-donation rates in the three groups within 2 months after the questionnaire delivery were analyzed by intention to treat (ITT) analysis and average treatment effect (ATT) estimation. 【Results】 The response rate of valid questionnaires was 5.422% (710/13 093), of which 7.424% (324/4 364) were in intervention group 1 and 8.845% (386/4 364) in intervention group 2. The collected questionnaire showed that the score of "blood donation can save lives" was the highest (2.31±0.79)in intervention group 1, and the score of "no blood donation site nearby" was the highest (2.31±0.80). in intervention group 2.2 months of observation showed that the re-donation rate was similar among all three groups by ITT analysis (Ps>0.05). ATT estimation results showed that the re-donation rates of intervention group 1 and intervention group 2 were 5.56%(18/324) and 3.11%(12/386), respectively(P<0.05). 【Conclusion】 Motivation questionnaire is a simple and convenient way to remind blood donors who have multiple donations to donate blood again.
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【Objective】 To investigate the changes of platelet, white blood cell, red blood cell counts, Hb and PCV before and after plateletpheresis donation. 【Methods】 10 444 platelet donors who donated platelet from Aug 1, 2019 to Jul 31, 2020 were selected as subjects, among which first-time donors were selected as control group and donors who donated twice or more as donation group. After matching gender and age using Propensity Score Matching method in the two groups, the changes of platelet, white blood cell, red blood cell counts, Hb and PCV of platelet blood donors were compared by t test. 【Results】 There were a slight increase in Plt (t=-6.651, P0.05) and in PCV (t=0.030, P>0.05) after plateletpheresis donation. 【Conclusion】 Plateletpheresis donation has an effect on some peripheral blood parameters, but within the normal reference range.
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【Objective】 To obtain HTLV prevalence data among blood donors in mainland China through meta-analyze, and provide reference for relevant policies. 【Methods】 The literature concerning HTLV prevalence among blood donors in mainland China before April 15, 2021 in CNKI, Wanfang and Pubmed was searched. According to the inclusion criteria and exclusion criteria, relative literature within recent 10 years was screened and then analyzed by meta-analysis using R3.3. 【Results】 A total of 69 articles were included, covering 22 provincial administrative regions, with a total sample size of 7 435 501 cases. 535 cases were HTLV positive, of which 491 centred on three coastal provinces as Fujian, Guangdong and Zhejiang, and 44 scattered in 11 other provincial administrative regions. The pooled prevalence of HTLV in blood donors in Fujian, Guangdong and Zhejiang provinces were 3.25/10 000(95%CI 1.91/10 000~4.58/10 000), 0.13/10 000(95%CI 0.09/10 000~0.17/10 000) and 0.33/10 000(95%CI 0.06/10 000~0.61/10 000), respectively. Subgroup analysis showed that the pooled prevalence of HTLV in Fujian blood donors decreased since December 2015. 【Conclusion】 Blood donors in mainland China present low HTLV prevalence, mainly distributed in three coastal provinces as Fujian, Guangdong and Zhejiang. The sample size tested increased greatly since HTLV screening for blood donors was popularized nationwide in blood stations in December 2015, the infection rate of HTLV in Fujian, however, did not increase as expected.
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【Objective】 To study and analyze the fluctuation of peripheral blood of apheresis platelet donors aged 56~60, so as to provide data support for safe recruitment and retention of elderly donorsin China. 【Methods】 Elderly apheresisplatelet donors, aged 56~60, donated for 6 769 occasions from 2017 to 2019 in Guangzhou Blood Center were analyzed retrospectively and grouped by gender and age. The fluctuation of peripheral blood was analyzed byone way ANOVA.Further pairwise comparison was carried out by Turky if there were statistical differences. 【Results】 All the peripheral blood levels were statistically significant between men and women aged around 56 (P<0.05). The Plt(×109 / L), RBC(×1012 / L) and Hb(g/L) of women after and before 56 were (274.33±49.47) vs (296.61±44.89), (4.48±0.35) vs (4.4±0.3), and (125.87±9.08) vs (128.33±8.79), respectively, and the differences were statistically significant (P<0.05), while no differences was noticed between them inWBC(×109 / L) and Hct, (6.29±1.36) vs (6.26±1.46) and (0.39±0.05) vs (0.39±0.02), respectively(P>0.05). The RBC(1012 / L), Hb(g/L), WBC(×109 / L) and Hctof men after and before 56 were (4.94±0.39) vs (4.91±0.35), (137.15±12.83) vs (141.29±10.67), (5.77±1.23) vs (6.03±1.26) and (0.42±0.03) vs (0.42±0.03), respectively, and the differences were statistically significant (P<0.05), and no significant difference was noticed in Plt(×109 / L)(283.94±59.63) vs (283.5±62.7)(P>0.05). There was no significant difference in Plt between men and women after 56 (P>0.05). The RBC, Hb and Hct of men around 56 were higher than those of women (P<0.05). The deferral rate of pretransfusion blood testing increased as the platelet donors were older than 56, showing statistical significance(P<0.05). 【Conclusion】 Fluctuation of peripheral blood levelof platelet donors aged 56~60 occurred when they were around 56 years old, but within the normal range.Therefore, blood donation is generally safe under the current policy. As the physiological regulation function of these donors has decreased, the monitoring of peripheral blood routine before and after blood donation needs to be strengthened to ensure blood quality and the health of elderly platelet donors.
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Objective:To explore the main influencing factors for physical performance assessed by the short physical performance battery(SPPB)in the elderly in communities in Shanghai.Methods:A total of 500 elderly subjects from four communities in Shanghai who met the inclusion criteria with 165 males and 335 females aged 60-95 years(70.5±7.8)years were enrolled.A questionnaire was used to assess the general situation.International Physical Activity Questionnaire-Short Form(IPAQ-SF)was used to assess physical activity(PA). The appendicular skeletal muscle mass(ASM)was measured by bioelectrical impedance analysis, and the relative skeletal muscle mass index(RSMI). The lower extremity muscle strength(quadriceps strength, QS)was measured by a hand-held dynamometer.Lower body muscle quality(LB-MQ) was ascertained by taking the ratio of strength to muscle mass for lower extremity.SPPB score was used to assess physical activity, including full tandem test, 4-meter walking speed test and five timed chair stands test.Results:The age, RSMI, ASM and quadriceps strength were higher, and the body fat content was lower in males than in females(all P<0.001). There were no significant differences in BMI, SPPB scores, LBMQ, and PA between males and females( P>0.05). Pearson correlation analysis showed that SPPB score was negatively correlated with age( r=-0.615, P<0.001)and body fat content( r=-0.103, P=0.022), but SPPB score was positively correlated with quadriceps strength( r=0.351, P<0.001), RSMI( r=0.134, P=0.003), LBMQ( r=0.268, P<0.001)and amount of PA( r=0.204, P<0.001), however, SPPB score had no relationship with gender( r=0.068, P=0.132). Conclusions:Aging and frailty are the main factors for the decline of physical performance in the elderly.Participating physical activity, reducing body fat, maintaining muscle mass, and especially increasing muscle quality, may be the main interventions to prevent the further deterioration of physical performance in the elderly.
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Henoch-schonlein purpura is the most common vasculitis in the childhood.The prognosis of Henoch-schonlein purpura is mainly dependent on the renal component of the disease, which is equal to the severity of Henoch-schonlein purpura nephritis(HSPN). To predict the outcome of the HSPN, the pathology of renal biopsy is still remaining the gold standard.The conventional histological classification of the International Study of Kidney Disease in Chlidren(ISKDC), which is facing severe challenges in evaluating the prognosis of the HSPN, is imprecise.So it′s very necessary to recognize the relationship between specific pathological changes and prognosis of HSPN.So we reviewed the relationship between specific pathological changes and the prognosis prediction of HSPN in this paper, hoping to guide the clinical work.
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BACKGROUND@#Virtual bronchoscopic navigation (VBN) assisted endobronchial ultrasonography with guide sheath (EBUS-GS) has reduced the difficulty and even avoiding radiation exposure during performing transbronchus lung biopsy (TBLB). To evaluate the feasibility and safety of virtual bronchoscopic navigation assisted endobronchial ultrasonography with guide sheath for peripheral pulmonary lesions.@*METHODS@#We performed a retrospective analysis of the patients with PPLs who received VBN assisted EBUS-GS-TBLB in Peking University Cancer Hospital from January 2016 to December 2017. Their clinicopathologic data and complications were assessed.@*RESULTS@#A total of 121 patients were enrolled in the study. The patients included 65 men and 56 women, with a mean age of (58.8±10.3) years. A total of 121 PPLs were examined, and 108 lesions of which could be detected by EBUS. The overall diagnostic yield of EBUS-GS was 73.5%. The diagnostic yield of malignancy was 82.5%. The combination of transbronchial lung biopsy, brush smear and bronchoalveolar lavage fluid provided the greatest diagnostic yield (χ²=6.084, P=0.014). Factors that significantly affected and predicted diagnostic success were EBUS probe within the lesions (χ²=20.372, P=0.000) and PPLs located in the central two-thirds of the lung (χ²=10.810, P=0.001). 1 patient (0.8%) suffered from intraoperative bleeding which could be managed under endoscopy.@*CONCLUSIONS@#VBN assisted EBUS-GS-TBLB for PPLs was an effective and safe procedure.
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Female , Humans , Male , Middle Aged , Bronchoscopy , Methods , Endosonography , Methods , Lung Neoplasms , Diagnostic Imaging , General Surgery , Retrospective Studies , SafetyABSTRACT
Objective@#To investigate the value of colonoscopic assessment in "watch and wait" strategy for mid-lower rectal cancer after neoadjuvant chemoradiotherapy (nCRT).@*Methods@#A single-center retrospective case series study was performed. Database of mid-lower rectal cancer patients at Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute from March 2011 to June 2017 was retrieved. Inclusion criteria: (1) nCRT was completed (50.6 Gy/22 f, plus oral capecitabine); (2) radical surgery was performed within 12 weeks after nCRT treatment; (3) clinical response to nCRT was determined as clinical complete response (cCR) or near-cCR. Patients who did not undergo colonoscopy and MRI in our center during initial assessment and follow-up, or whose colonoscopy data were unable to re-evaluated, were excluded. Initial evaluation of nCRT response was carried out between 6 and 16 weeks after nCRT. The results of endoscopy (eCR, near-eCR and non-eCR) and MRI (mCR, near-mCR and non-mCR) were compared to local lesion relapse during follow-up. The consistency of the results of colonoscopy and MRI was evaluated by Kappa test (Kappa value of 0.21 to 0.40 indicates general consistency, 0.41 to 0.60 moderate consistency, and 0.61 to 0.80 high consistency). The non-regrowth disease-free survival (NR-DFS) curves of the eCR group and the near-eCR group were plotted by Kaplan-Meier method and compared by log-rank test. Clinical significance of colonoscopy examination in the following "watch and wait" strategy during follow-up period was analyzed.@*Results@#A total of 32 patients were enrolled in the study, including 21 (65.6%) males and 11 (34.4%) females with a median age of 57 years old. The differentiated type of rectal cancer included 1 (3.1%) case of well-differentiated, 26 (81.2%) of moderately differentiated and 5 (15.6%) of poorly differentiated. Clinical stage of the patients included 9 (28.1%) cases of T2-3N0 and 23 (71.9%) of T2-3N+. Median follow-up period was 48 (18 to 80) months. The local regrowth rate was 34.4% (11/32) and median interval of local regrowth was 10.0 (4 to 37) months. Initial colonoscopy evaluation was carried out at a median time of 9 (5 to 19) weeks after nCRT was completed. According to endoscopic findings, patients were divided into 3 groups, including 15 cases in eCR group, 15 cases in near-eCR group and 2 cases in non-eCR group. According to the appearance of MRI, patients were divided into 3 groups, including 8 cases in mCR group, 21 cases in near-mCR group and 3 cases in non-mCR group. The regrowth rate of eCR group was lower than that of mCR group (1/15 vs. 1/8) without significant difference (P=1.000). The regrowth rate of near-eCR group was higher than that of near-mCR group [9/15 vs. 42.9% (9/21)] without significant difference as well (P=0.500). The consistency between colonoscopy and MRI in response evaluation of cCR or near-cCR after nCRT was unsatisfactory (Kappa=0.341, P=0.011). After initial evaluation, 31 patients underwent watch and wait strategy, and 1 underwent local resection. The 1- and 3-year NR-DFS in the eCR group was both 100%, which was higher than that in the near-eCR group (53.3% and 38.9%, respectively), and the difference was statistically significant (P=0.001). During watch and wait period, 11 cases developed local regrowth by colonoscopy examination and the biopsy result included 4 case of high-grade intraepithelial neoplasia (HIN), 6 cases of adenocarcinoma and 1 case of chronic mucosal inflammation. Meanwhile lateral developmental tumor of ascending colon in 1 case and of sigmoid in a case was found by colonoscopy and confirmed as HIN by postoperative pathology. Besides, 4 cases developed colonic multiple adenoma and all underwent endoscopic resection.@*Conclusion@#Colonoscopy examination plays an important role in both initial assessment and regrowth monitoring during watch and wait strategy after nCRT treatment.
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0bjective To explore the effect of brain health education on therapeutic adherence of hypertensive patients with subjective memory complaints based on health belief model. Methods A randomized controlled trial was designed in this study. eligible patients were selected from a community health service center in Chongqing were randomly assigned to intervention group (56 cases) and control group (60 cases). The control group received routine community health services and the intervention group received brain health education on the basis of the control group. statistical analysis was performed on the patients' dementia risk control belief, therapeutic adherence, and blood pressure control rate at baseline, after the group intervention, and after the individualized telephone intervention. Results There was a significant group× time interaction(F 交互=12.353, 22.376, P<0.05) on dementia risk control belief and therapeutic adherence (P<0.05),. The dementia risk control belief score, the therapeutic adherence and the blood pressure control rate in the intervention group was (98.74±13.62), (119.26±4.93) points and 70.0% , the control group was (85.00 ± 12.80), (106.48 ± 10.33) points and 50.0% after the intervention; the intervention group was higher than the control group (t=5.194, t=7.899, χ2=4.167, P<0.05). The subjects were rated at 4 points and above for each item of satisfaction with the project after the intervention. Conclusions Brain health education based on health belief model in hypertensive patients with subjective memory complaints, can effectively improve the dementia risk control belief and therapeutic adherence, and promote the self-management of blood pressure control.
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Objective To explore the short-term efficacy of Xiaoaiping injection assisted TP regimen (taxotere + paraplatin)in the treatment of advanced non-small cell lung cancer(NSCLC)and its effects on immune function,adverse reactions and quality of life. Methods One-hundred cases of patients with advanced NSCLC who were admitted to the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from October 2014 to October 2017 were selected as subjects,and they were randomly divided into Xiaoaiping group (n = 55)and TP group(n = 45)according to the random number table method. Patients in TP group were given TP regimen chemotherapy,and patients in Xiaoaiping group were added with Xiaoaiping injection on the basis of TP group. The short-term efficacy and changes of immune function,adverse reactions and quality of life were observed in the two groups,and statistical comparison was performed. Results After treatment,the response rates of patients in Xiaoaiping group and TP group were 49. 09％(27 / 55)and 28. 89％(13 / 45) respectively,with a significant difference(χ2 = 4. 209,P = 0. 040). After treatment,the disease control rates of patients in Xiaoaiping group and TP group were 83. 64％(46 / 55)and 73. 33％(33 / 45)respectively,with no significant difference(χ2 = 1. 584,P = 0. 208). The CD4 +(40. 98％ ± 5. 73％ vs. 33. 47％ ± 5. 06％ ), CD4 + / CD8 +(1. 53 ±0. 34 vs. 1. 25 ±0. 26)and nature killer(NK)cells(19. 59％ ± 4. 77％ vs. 17. 05％ ± 4. 12％ )in Xiaoaiping group after treatment were significantly higher than those in TP group(t = 6. 869,P <0. 001;t = 4. 542,P < 0. 001;t = 5. 609,P < 0. 001). And there was no significant difference in CD8 +between the two groups(26. 83％ ± 5. 21％ vs. 26. 58％ ± 5. 20％ ;t = 0. 239,P = 0. 812). The incidence rates of leucopenia(50. 91％ vs. 75. 56％ ),thrombocytopenia(38. 18％ vs. 66. 67％ )and hemoglobin re-duction(52. 73％ vs. 77. 78％ )in Xiaoaiping group were lower than those in TP group,with significant diffe-rences(χ2 = 6. 381,P = 0. 012;χ2 = 8. 306,P = 0. 005;χ2 = 6. 741,P = 0. 009). There were no significant differences in the incidence rates of nausea and vomiting(32. 73％ vs. 48. 89％ ),diarrhea constipation (45. 45％ vs. 60. 00％ )and liver damage(7. 27％ vs. 13. 33％ )between the two groups(χ2 = 2. 694,P =0. 101;χ2 = 2. 098,P = 0. 148;χ2 = 0. 449,P = 0. 503). After treatment,the Karnofsky functional status scores of patients in Xiaoaiping group and TP group were 81. 47 ± 11. 26 and 73. 38 ± 10. 45 respectively,and the stability rates of quality of life improvement were 78. 18％(43 / 55)and 57. 78％(26 / 45)respectively, with significant differences(t = 3. 691,P < 0. 001;χ2 = 4. 817,P = 0. 028). Conclusion Xiaoaiping injec-tion assisted TP regimen has a good short-term efficacy on advanced NSCLC,which can effectively improve immune function,reduce adverse reactions and improve the quality of life.
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OBJECTIVE@#To investigate the long-term outcome of organ preservation with local excision or "watch and wait" strategy for mid-low rectal cancer patients evaluated as clinical complete remission (cCR) or near-cCR following neoadjuvant chemoradiotherapy (NCRT).@*METHODS@#Clinical data of 62 mid-low rectal cancer patients evaluated as cCR/near-cCR after NCRT undergoing organ preservation surgery with local excision or receiving "watch and wait" strategy at Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute from March 2011 to August 2017 were retrospectively analyzed. According to the approximate 1:2 pairing, 123 patients who underwent radical resection with complete pathological remission(ypCR) after neoadjuvant chemotherapy during the same period were selected for prognosis comparison. The primary endpoint of the study was 3-year non-regrowth disease-free survival (NR-DFS) and tumor specific survival (CSS). Survival analysis was performed using the Kaplan-Meier curve (Log-rank method). The secondary endpoint of the study was 3-year organ preservation and sphincter preservation.@*RESULTS@#The retrospective study included 38 male and 24 female patients. The median age was 60 (31-79) years and the median distance from tumor to anal verge was 4(1-8) cm. The ratio of cCR and near-cCR was 79.0%(49/62) and 21.0%(13/62) respectively. Local regrowth rate was 24.2%(15/62). Of 15 with tumor regrowth, 9 patients received salvage radical rectal resection and no local recurrence was found during follow-up; 4 patients received salvage local excision among whom one patient had a local recurrence occurred patient; 2 patients refused further surgery. The overall metastasis rate was 8.1%(5/62), including resectable metastasis(4.8%,3/62) and unresectable metastasis (3.2%,2/62). The valid 3-year organ preservation rate and sphincter preservation rate were 85.5%(53/62) and 95.2%(59/62) respectively. The median follow-up was 36.2(8.6-89.0) months. The 3-year NR-DFS of patients with cCR and near-cCR was 88.6% and 83.1% respectively, which was not significantly different to that of patients with ypCR (94.7%, P=0.217). The 3-year CSS of patients with cCR and near-cCR was both 100%, which was not significantly different to that of patients with ypCR(93.4%, P=0.186).@*CONCLUSIONS@#Mid-low rectal cancer patients with cCR or near-cCR after NCRT undergoing organ preservation with local excision or receiving "watch and wait" strategy have good long-term prognosis with low rates of local tumor regrowth and distant metastasis, which is similar to those with ypCR after radical surgery. This treatment mode may be used as an option for organ preservation in mid-low rectal cancer patients with good tumor remission after NCRT.